Parts of the Kantamanto market in the Accra Central Business District has been burnt down by fire.
The inferno, according to an eyewitness, started from a place close to the Agbogbloshie Market at about 10pm Monday night.
Though there were no casualties, property and goods running into hundreds of thousands of cedis have been lost as the fire razed many shops.
The cause of the fire remains yet unknown.
This comes just a day after fire burnt down about eight shops at Koforidua in the Eastern Region.
Just a month a go, a fire outbreak swept through the GCB Bank tower at Kantamanto in Accra.
Meanwhile, a section of Ghanaians have taken to social media to express their concern over the development.